Nonsteroidal Anti-inflammatory Drugs are Often the First Line of Defense
During the early stages of the disease, mild inflammation may respond to nonsteroidal anti-inflammatory drugs (NSAIDs) that are available over-the-counter or in stronger doses by prescription. Theses drugs include aspirin, ibuprofen (Advil®, Motrin®) and naproxen (Aleve®, Naprosyn®). These drugs can decrease inflammation, reduce joint pain, and help to alleviate the morning stiffness that is commonly associated with psoriatic arthritis.
Because taking NSAIDs in high doses or for extended periods of time can have side effects, they are not for everybody. A newer type of NSAID, called a COX-2 inhibitor, has proven useful without the side effects associated with older NSAIDs, but they are more expensive and carry their own set of risks. Fortunately, other medications are available as well.
Treatment Options for the More Severe Forms of the Disease
Disease-modifying antirheumatic drugs (DMARDs) comprise several classes of medications that work by altering the way the immune system functions in an attempt to stop the underlying processes that cause the joint and tissue damage associated with psoriatic arthritis. They are often indicated as the second line of treatment for patients who are unresponsive to NSAID therapy or who have a more destructive form of the disease.